2014 October

Factors of Lesions Caused by Psoriasis Found

We at Eastside Dermatology know how troubling having psoriasis can be for an individual. We offer treatments for all different severities of the disease.

Psoriasis is an uncomfortable and embarrassing skin disorder that causes skin cells to grow too fast, which results in thick, white, silvery, or red patches on the skin. Psoriasis affects roughly 3 percent of the world’s population. However, researches have recently found the underlying genetic factors that aid in the repair of skin lesions cause by psoriasis.

Dr. Bogi Anderson, who is a professor of biological chemistry and endocrinology at UCI, along with his colleagues, found out that a gene called grainyhead is responsible for triggering a repair pathway for psoriasis lesions. Grainyhead is known to be a major part in the epidermal development and healing of wounds. They also found that getting rid of this gene amplified the brutality and time of the embarrassing patches. But what does this mean?

These researchers learned that within psoriasis, there is a compound called grainyhead-like-3, which attaches to your DNA to help control the rate of transcription of genetic information from your DNA to the messenger RNA. Essentially, it arranges the initiation of an epidermal repair pathway. The gene was originally found in fruit flies, where it assisted in wound healing.

Researchers have also found out that it is easier to stimulate psoriasis like symptoms in mice that lack the GRHL3 gene. This means that the lesions did not disappear properly and remained visible even during an active immune suppression treatment, which is currently being studied for the disease.

This study shows us that an evolutionary epidermal repair pathway is created in psoriasis lesions and that this pathway helps tame the disease’s severity. It also helps clear up the lesions. Through this study, it is speculated that irregularities in this pathway may contribute psoriasis’s severity and that in the future this could help to treat the disease.


NEW: XTRAC Laser Services

XTRAC is the only FDA-cleared, clinically proven excimer laser that gets skin clear of psoriasis—and it works fast, with many patients seeing significant improvement and long-lasting remissions. Because XTRAC delivers a highly targeted, therapeutic beam of UVB light only to areas of the skin affected by psoriasis, healthy skin surrounding the lesions stays that way.

XTRAC clears the symptoms, prolongs the remission and returns skin to a clinically healthy state in record time. All of which means XTRAC delivers consistently predictable results so patients experience more good days of living than bad.

Quick Facts

  • Effective treatment—symptoms reduced generally in 10-12 treatment sessions
  • Long-lasting relief—typically several months free of symptoms”
  • Simple, painless treatment—sessions are very short
  • Relief without messy creams and daily skin care regimen
  • Covered by most major insurance companies, available by Rx


*Results may vary, talk to your doctor about the right treatment protocol for you.

Side Effects/Risks: XTRAC has none of the drawbacks often associated with other psoriasis treatments-such as premature aging of healthy skin, skin thinning, resistance to medication, or potential negative systemic side effects. Some patients, however, experience a reaction similar to sunburn or blistering at the site of the treated area and in some cases, an increase in pigmentation may occur.


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Our Locations

Two convenient locations to better serve you:

150 Taylor Station Rd. Suite 250
Ohio 43213

4617 Leap Ct.,
Ohio 43026

Our Promise

At Eastside Dermatology, Dr. Alan Parks and his entire team are dedicated to providing the highest quality cosmetic and surgical skin care for their Columbus and Hilliard, Ohio-area patients.

Eastside Dermatology & Skin Care Center is associated with the DocShop patient education network. is an informational resource for patients considering dermatology treatments.

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